The lysine 831 of vascular endothelial growth factor receptor 1 is a novel target of methylation by SMYD3. And whereas I do hear and respect to science and analysis, I also take heed to and respect people's actual life and first hand experiences. Methylation been discovered on a variety of lysine residues in varied histones: K4 (using the only-letter amino-acid code for lysine), K9, K27, K36 and K79 in histone H3, K20 in histone H4, K59 in the globular domain of histone H4 2 and K26 of histone H1B 3 A number of proteins chargeable for the methylation of specific residues have been characterised, and all but one of these accommodates a SET domain